Functional neuroanatomical profiling of compounds using non invasive imaging

Fos staining in cortex

Changes in expression of activity-dependent genes are used to map neuronal activity changes induced by various compounds.

This enables to :

  • Examine whether compounds injected systemically cross the blood brain barrier
  • Identifiy candidate brain regions targeted by the compound
  • Compare the neuronal activity profile of the drug of interest with existing reference compounds or classes of compounds

Effects of compounds on adult hippocampal neurogenesis

Analyses of staining and cell counting

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